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. 2008 Aug 5;6(8):e191. doi: 10.1371/journal.pbio.0060191

Figure 5. AIRE Is Not Necessary for Tolerance to Antigens Expressed by TSCOT+ TECs.

Figure 5

Proliferation assays in response to β-gal for lymph node CD4+ T cells from LacZ-immunized (10 μg) wild-type (rectangles), TDLacZ (ovals), or AIRE-deficient (triangles), or from AIRE-deficient × TDLacZ (inverted triangles) mice. The responses of the LacZ-immunized mice (+Ag) are shown as solid lines with closed symbols, while those of the adjuvant-only immunized mice (−Ag) are shown as dotted lines with open symbols.