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. Author manuscript; available in PMC: 2009 Jun 5.
Published in final edited form as: Brain Res. 2008 Apr 1;1213:1–11. doi: 10.1016/j.brainres.2008.03.034

Figure 1.

Figure 1

Time-dependent increases in CSF 14-3-3β, 14-3-3ζ, cleaved α-spectrin, and UCH-L1 following aortic aneurysm surgical repair. Western blot analysis of unfractionated lumbar CSF samples taken at the indicated times following aortic cross-clamping. (Top) The cases shown in red included cardiopulmonary bypass with DHCA. The levels of 14-3-3β, ζ and cleaved α-spectrin were near or below the lower limit of detection prior to the onset of the surgical procedures. Note that for a subset of surgical cases, there are coordinate increases in the levels of the three biomarkers between 2–24 hours after the beginning of surgery. (Bottom) Western analysis of CSF levels of the neuron-enriched deubiquinating enzyme UCH-L1. Shown are 5 representative cases, two of which exhibit a time-dependent increase in the ~25 kDa UCH-L1 polypeptide of >3-fold.