Table 3.

Lip purse: paired t-tests of activation (baseline minus follow up), with pain scores as covariates

Anatomical site	Contemporaneous pain				Constant pain NRS				Constant unpleasantness				Exacerbation Pain NRS				Exacerbation unpleasantness
	Z	x	y	z	Z	x	y	z	Z	x	y	z	Z	x	y	z	Z	x	y	z
L M1 hand/arm	×	×	×	×	2.5	−24	−38	50	×	×	×	×	×	×	×	×	×	×	×	×
L S1 hand/arm	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×
R M1 hand/arm	2.8	26	−30	54	3.0	24	−32	56	×	×	×	×	×	×	×	×	2.3	26	−30	54
R S1 hand/arm	3.0	28	−30	60	3.8	20	−28	60	×	×	×	×	×	×	×	×	2.6	24	−34	62
R ACC	3.4	2	−22	42	4.1	6	10	32	3.6	4	12	32	×	×	×	×	3.5	4	12	32
L ACC	3.9	−10	10	30	3.9	−4	2	38	3.1	−2	−8	42	3.5	−2	−2	34	4.4	0	−12	34
L insula	4.8	−36	2	6	×	×	×	×	3.6	−44	14	–16	3.9	−50	12	−6	4.0	−50	12	−6
R insula	×	×	×	×	3.6	54	−14	10	×	×	×	×	×	×	×	×	3.7	50	14	−6
L thalamus	3.1	−16	−22	4	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×
L superior temporal	4.1	−58	10	−10	4.1	−42	14	−16	×	×	×	×	3.7	−50	14	−16	3.5	−56	8	−12
R superior temporal	×	×	×	×	×	×	×	×	3.6	8	−78	24	×	×	×	×	×	×	×	×
L S II	3.6	−32	−30	42	×	×	×	×	3.5	−12	−42	48	3.7	−10	−42	50	×	×	×	×
L inferior Frontal	4.1	−46	−2	26	×	×	×	×	×	×	×	×	×	×	×	×	3.8	58	0	10
R inferior Frontal	×	×	×	×	3.7	54	4	10	×	×	×	×	×	×	×	×	×	×	×	×
SMA	4.2	0	−2	50	3.9	−10	−8	56	3.1	−4	−28	62	3.7	0	−6	42	×	×	×	×
Premotor Area	3.9	−22	−12	4	4.0	14	−22	62	×	×	×	×	×	×	×	×	×	×	×	×

Brain areas in which reduction in activation at follow up covaried with pain reduction after therapy, measured by paired t-tests using the GLM within FSL software, with pain scores added as a regressor; × = no significant activation.