Table 1.
Clincial, MR spectroscopy, and MR imaging parameters at baseline and during partial insulin deprivation
| Baseline | Partial insulin deprivation | P | |
|---|---|---|---|
| Clinical characteristics | |||
| Age (years) | 41 ± 3 | — | — |
| A1C (%) | 7.4 ± 0.2 | — | — |
| Duration of diabetes (years) | 21.7 ± 2.3 | — | — |
| BMI (kg/m2) | 23.5 ± 0.6 | 23.0 ± 0.8 | 0.1 |
| Mean 24-h glucose (mmol/l) | 8.4 ± 0.6 | 15.9 ± 0.8 | < 0.001 |
| Mean 24-h insulin (units/l) | 45 ± 5 | 27 ± 5 | < 0.001 |
| NEFAs (mmol/l) | 0.31 ± 0.05 | 0.46 ± 0.07 | 0.015 |
| TG (mmol/l) | 1.03 ± 0.24 | 0.85 ± 0.49 | 0.2 |
| Total cholesterol (mmol/l) | 4.3 ± 0.2 | 4.4 ± 0.2 | 0.1 |
| Systolic blood pressure (mmHg) | 114 ± 4 | 118 ± 5 | 0.2 |
| Diastolic blood pressure (mmHg) | 68 ± 3 | 73 ± 3 | 0.1 |
| Heart rate (bpm) | 63 ± 1 | 60 ± 3 | 0.3 |
| MR spectroscopy | |||
| Liver TG content (%) | 0.77 ± 0.09 | 0.84 ± 0.11 | 0.4 |
| Myocardial TG content (%) | 0.31 ± 0.04 | 0.34 ± 0.06 | 0.6 |
| MR imaging | |||
| LV ejection fraction (%) | 58 ± 1 | 59 ± 2 | 0.6 |
| E peak filling rate (ml/s) | 475 ± 21 | 467 ± 20 | 0.6 |
| E deceleration (ml/s2 × 10−3) | 4.4 ± 0.4 | 4.5 ± 0.3 | 0.8 |
| A peak filling rate (ml/s) | 267 ± 21 | 254 ± 38 | 0.7 |
| E/A peak ratio | 1.9 ± 0.2 | 1.9 ± 0.3 | 0.9 |
Data are means ± SEM. Blood samples were obtained 2 h after the last meal. NEFA, nonesterified fatty acid.