Table 1.
Characteristics of study participants aged 50–89 years and the 10-, 20-, and 30-year risk of CVD by diabetes status†
| Nondiabetic
|
Diabetic
|
Nondiabetic
|
Diabetic
|
|
|---|---|---|---|---|
| Women | Men | |||
| Baseline characteristics and follow-up information | ||||
| Original cohort | ||||
| Normal weight | 1225 (48.0) | 73 (33.2) | 694 (35.6) | 35 (17.5) |
| Overweight | 880 (34.5) | 69 (31.4) | 998 (51.3) | 113 (56.5) |
| Obese | 448 (17.6) | 78 (35.5) | 256 (13.1) | 52 (26.0) |
| New CVD events | 1424 | 159 | 1267 | 146 |
| Person-years follow-up | 63765 | 2778 | 39685 | 2248 |
| Offspring | ||||
| Normal weight | 931 (49.6) | 40 (19.8) | 399 (24.5) | 39 (15.2) |
| Overweight | 593 (31.6) | 63 (31.2) | 858 (52.6) | 121 (47.3) |
| Obese | 353 (18.8) | 99 (49.0) | 373 (22.9) | 96 (37.5) |
| New CVD events | 244 | 52 | 387 | 102 |
| Person-years follow-up | 28229 | 2027 | 23408 | 2573 |
| Lifetime risk CVD* | ||||
| Original cohort | ||||
| 10-year | 6.9 (5.8–7.9) | 21.6 (9.5–33.6) | 15.0 (13.3–16.8) | 28.2 (15.4–41.1) |
| 20-year | 21.7 (20.1–23.4) | 50.0 (39.2–60.9) | 36.0 (33.8–38.2) | 57.7 (47.7–67.7) |
| 30-year | 38.0 (36.1–39.9) | 67.1 (58.3–76.0) | 54.8 (52.5–57.0) | 78.0 (71.5–84.4) |
| Offspring | ||||
| 10-year | 3.9 (3.0–4.9) | 15.9 (7.2–24.6) | 8.7 (7.1–10.2) | 13.3 (7.1–19.5) |
| 20-year | 11.0 (9.2–12.7) | 29.3 (19.8–38.7) | 23.7 (21.3–26.2) | 43.8 (36.1–51.6) |
| 30-year | 26.0 (22.6–29.4) | 48.6 (38.5–58.7) | 37.8 (34.3–41.3) | 61.6 (53.9–69.3) |
| Lifetime risk of CVD stratified by BMI category* | ||||
| 10-year | ||||
| Normal weight | 6.2 (4.7–7.6) | 9.4 (0.0–22.1) | 11.9 (9.3–14.5) | 33.2 (6.3–60.0) |
| Overweight | 6.8 (5.0–8.6) | 16.5 (0.0–34.1) | 15.1 (12.7–17.5) | 21.5 (5.9–37.0) |
| Obese | 9.3 (6.3–12.3) | 41.9 (14.2–69.6) | 22.8 (17.0–28.5) | 47.6 (12.1–83.2) |
| 20-year | ||||
| Normal weight | 18.8 (16.6–21.1) | 33.7 (16.2–51.2) | 30.9 (27.4–34.4) | 54.0 (30.1–77.9) |
| Overweight | 21.6 (18.9–24.4) | 52.2 (34.6–69.9) | 37.3 (34.2–40.3) | 57.9 (45.4–70.4) |
| Obese | 30.0 (25.6–34.3) | 65.6 (47.1–84.1) | 44.4 (37.9–50.8) | 65.4 (40.2–90.6) |
| 30-year | ||||
| Normal weight | 34.3 (31.6–37.0) | 54.8 (39.0–70.5) | 49.2 (45.4–52.9) | 78.6 (63.7–93.4) |
| Overweight | 38.7 (35.5–41.9) | 69.3 (55.9–82.7) | 55.5 (52.4–58.6) | 74.0 (64.8–83.3) |
| Obese | 46.7 (42.1–51.4) | 78.8 (66.4–91.2) | 66.8 (60.7–73.0) | 86.9 (75.8–97.9) |
Data aren, n (%), and odds ratio (95% CI).
*
Expressed as percent developing CVD, adjusted for the competing risk of death. For original cohort and offspring among participants aged 50–89 years, 95% CIs are stratified by BMI category for the offspring cohort only.
†
In the original cohort, 0.08% of participants were lost to follow-up, and in the offspring cohort, 0.5% of participants were lost to follow-up. In the original cohort, 10.3% of CVD events were fatal and in the offspring cohort, 5.4% were fatal.