Table 1.
Clinical characteristics of young subjects with type 1 diabetes with and without abnormal PFT
| Normal PFT | Abnormal PFT | Total | P value | |
|---|---|---|---|---|
| n | 172 | 159 | 331 | |
| Age (years) | 15.7 (13.5–17.3) | 15.1 (13.5–17.3) | 15.4 (13.5–17.3) | 0.46 |
| Sex (male/female) | 62/110 | 100/59 | 172/159 | <0.001 |
| Diabetes duration (years) | 7.6 (5.0–10.3) | 7.9 (4.3–11.0) | 7.6 (4.9–10.6) | 0.77 |
| A1C (%) | 8.6 ± 1.3 | 8.5 ± 1.1 | 8.6 ± 1.3 | 0.69 |
| Total cholesterol (mmol/l) | 4.3 (3.9–5.0) | 4.3 (3.8–4.8) | 4.3 (3.8–4.9) | 0.42 |
| SBP (percentile) | 54 (27–82) | 71 (38–85) | 59 (32–82) | 0.004 |
| DBP (percentile) | 73 (48–83) | 73 (48–87) | 73 (48–84) | 0.49 |
| BMI (percentile) | 74 (56–87) | 78 (63–91) | 76 (61–88) | 0.02 |
| PON1 activity* | ||||
| Paraoxon (units/ml) | 39.6 (28.3–79.3) | 45.4 (28.1–85.4) | 41.4 (28.4–79.9) | 0.41 |
| Phenylacetate (units/ml) | 64.9 (44.6–81.6) | 70.6 (56.7–80.4) | 66.7 (52.8–80.5) | 0.26 |
Data are means ± SD or median (interquartile range).
*
PON1 activity was measured in 144 subjects.