Table 2.
Magnetic resonance spectroscopy measurements on muscle in people with and without type 2 diabetes before and after 2 and 8 weeks of increased physical activity
| Resting data | Type 2 diabetic subjects
|
Control subjects
|
||||
|---|---|---|---|---|---|---|
| Baseline | 2 weeks | 8 weeks | Baseline | 2 weeks | 8 weeks | |
| ADP (μmol/l) | 9.54 ± 0.17 | 9.75 ± 0.13 | 9.47 ± 0.12 | 9.38 ± 0.18 | 9.43 ± 0.13 | 9.33 ± 0.12 |
| pH | 7.04 ± 0.01 | 7.05 ± 0.01 | 7.04 ± 0.01 | 7.03 ± 0.01 | 7.03 ± 0.01 | 7.03 ± 0.01 |
| IMCL (relative to H2O) | 0.032 ± 0.006 | 0.035 ± 0.009 | 0.029 ± 0.003 | 0.037 ± 0.005 | 0.037 ± 0.004 | 0.038 ± 0.005 |
| End-exercise data | ||||||
| End-exercise ADP (μmol/l) | 33.3 ± 5.1 | 33.4 ± 4.9 | 36.8 ± 4.8 | 34.8 ± 3.7 | 33.9 ± 4.7 | 38.9 ± 3.8 |
| PCr use during exercise (% resting) | 25 ± 4 | 27 ± 5 | 29 ± 4 | 27 ± 3 | 25 ± 3 | 29 ± 3 |
| Glucose control | ||||||
| A1C (%) | 6.7 ± 0.3* | 6.7 ± 0.3* | 6.6 ± 0.2* | 5.7 ± 0.1 | 5.7 ± 0.1 | 5.6 ± 0.1 |
| Fasting glucose (mmol/l) | 7.1 ± 0.4* | 7.0 ± 0.4* | 6.5 ± 0.5 | 5.5 ± 0.2 | 5.7 ± 0.2 | 5.5 ± 0.2 |
| Insulin (mu/l) | 13.9 ± 3.5 | 13.1 ± 2.2 | 11.7 ± 2.3 | 8.1 ± 1.4 | 10.2 ± 3.0 | 7.6 ± 1.5 |
| Homeostasis model assessment | 4.4 ± 1.1* | 4.2 ± 0.8* | 3.4 ± 0.8* | 2.0 ± 0.4 | 2.1 ± 0.4 | 1.9 ± 0.4 |
Data are means ± SE.
*
Significantly different from people without diabetes (P < 0.05).