Table 2.

The association of insulin sensitivity index (M/I) and GFR: multivariable linear regression

Model	Total cohort (n = 1,070)		Normal fasting glucose and normal glucose tolerance (n = 517)		Normal fasting glucose, normal glucose tolerance, and GFR>50 ml/min per 1.73m2 (n = 433)
	β coefficient (95% CI)	P	β coefficient (95% CI)	P	β coefficient (95% CI)	P
A	0.86 (0.53–1.19)	<0.001	1.03 (0.57–1.50)	<0.001	0.52 (0.11–0.93)	0.01
B	1.10 (0.67–1.53)	<0.001	0.79 (0.25–1.33)	0.004	0.54 (0.07–1.00)	0.02
C	0.85 (0.52–1.19)	<0.001	1.03 (0.56–1.56)	<0.001	0.55 (0.14–0.97)	0.01
D	0.88 (0.45–1.31)	<0.001	1.09 (0.51–1.67)	<0.001	0.61 (0.11–1.10)	0.02
E	1.19 (0.69–1.68)	<0.001	0.86 (0.23–1.49)	0.007	0.66 (0.12–1.19)	0.02

Data are regression coefficients for a 1-unit higher M/I. Model A is adjusted for age, model B is adjusted for age and glucometabolic factors (fasting plasma glucose, fasting plasma insulin, and 2-h plasma glucose at OGTT), model C is adjusted for age and cardiovascular risk factors (hypertension, dyslipidemia, and smoking), model D is adjusted for age and lifestyle factors (BMI, physical activity, and consumption of tea, coffee and alcohol), and model E is adjusted for all covariates in models A–D.