FIG. 1.

Effect of maternal diabetes on blood pressure levels in the offspring. Systolic blood pressure significantly increased from 6 months in the offspring from diabetic mothers (diabetic mother offspring group, ▪) compared with control mother offspring group (□). Results are expressed as means ± SE, n = 4–10 animals in each group, issued from two or three litters. Two-way ANOVA: age effect, P < 0.0001; group effect, P < 0.0001; age × group interaction, P < 0.0001; unpaired t test between age-matched groups, ***P < 0.001, ****P < 0.0001.