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. 2008 Aug;57(8):2167–2175. doi: 10.2337/db07-0780

FIG. 2.

FIG. 2.

Effect of high-sodium diet on systolic blood pressure and on sodium urinary excretion. A: Systolic blood pressure was measured in 3-month-old rats under 0.3% sodium diet (0.3% Na) and after 7 days of sodium-rich diet (3% Na) in control mother offspring (□) and diabetic mother offspring (▪). Sodium-rich diet induced a significant increase of systolic blood pressure in 3-month-old diabetic mother offspring rats (n = 6 in each group, issued from two litters, paired t test: **P < 0.01) and remains ineffective on systolic blood pressure of control mother offspring rats. B: Natriuresis was followed for 3 days after the onset of high-sodium diet in the same groups of animals (control mother offspring, plain line; diabetic mother offspring, hatched line). Sodium urinary excretion was impaired in diabetic mother offspring rats compared with control mother offspring rats (n = 6 in each group, issued from two litters). Two-way ANOVA: time effect, P < 0.0001; group effect, P < 0.05; time × group interaction, P = 0.09; and unpaired t test in age-matched animals, *P < 0.05, ***P < 0.001.