TABLE 3.
Creatinine clearance and proteinuria
| Age (months)
|
ANOVA
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 6 | 9 | 12 | 18 | Age | Group | Interaction | ||
| Creatinine clearance (ml/min) | CMO | 0.76 ± 0.03 | 1.33 ± 0.04 | 2.21 ± 0.13 | 2.72 ± 0.20 | 3.02 ± 0.23 | 2.99 ± 0.27 | |||
| n | 5 | 5 | 6 | 6 | 6 | 4 | ||||
| DMO | 0.76 ± 0.12 | 1.21 ± 0.10 | 1.66 ± 0.08* | 1.75 ± 0.06† | 2.20 ± 0.18‡ | 2.04 ± 0.22 | P < 0.0001 | P < 0.001 | P = 0.0069 | |
| n | 6 | 4 | 6 | 4 | 5 | 4 | ||||
| Proteinuria (mg/day) | CMO | 4.52 ± 0.31 | 11.0 ± 0.45 | 12.5 ± 1.20 | 14.8 ± 2.08 | 18.3 ± 2.75 | 26.5 ± 2.53 | |||
| n | 5 | 5 | 6 | 6 | 6 | 4 | ||||
| DMO | 4.77 ± 0.82 | 14.7 ± 0.04* | 18.4 ± 1.34‡ | 23.3 ± 3.92 | 15.3 ± 1.55 | 57.2 ± 24.4 | P < 0.0001 | P = 0.0112 | P = 0.054 | |
| n | 6 | 4 | 6 | 4 | 5 | 4 | ||||
Data are means ± SE of n rats issued from two or three litters. CMO, control mother offspring; DMO, diabetic mother offspring. Two-way ANOVA with age and group effects. Comparisons are made between CMO and DMO at the same age (unpaired t test,
*
P < 0.001;
†
P < 0.01;
‡
P < 0.05).