FIG. 4.

Human duct cell grafts express IL-8 and VEGF after transplantation. Human duct cells were transplanted under the kidney capsule of NOD/scid mice. A: At indicated times, grafts were explanted and total RNA extracted and reverse transcribed to cDNA. IL-8 and VEGF gene expression levels were assessed by real-time PCR and normalized to HPRT. Values are means of four animals per time point. Figure represents three independent experiments. P vs. basal condition: *P ≤ 0.05; #P ≤ 0.001. At indicated time points, blood was taken from transplanted animals and serum assayed for human IL-8 and VEGF. Each dot represents an individual serum concentration value. Horizontal lines represent median. B: P vs. initial time point: *P ≤ 0.05; #P ≤ 0.001.