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. 2008 Aug;57(8):2046–2054. doi: 10.2337/db07-1824

FIG. 6.

FIG. 6.

Effect of ARC GLP-1 on peripheral glucose homeostasis during a hyperinsulinemic-euglycemic clamp. A: Glucose infusion rate during the glucose clamp was similar between the three groups. B: Glucose production was significantly reduced in ARC GLP-1 versus both saline and i3vt GLP-1 groups. C: Glucose uptake was significantly reduced in ARC and i3vt GLP-1 vs. saline. D: Glucose infusion rate during the hyperinsulinemic-eulgycemic clamp was similar between saline, ARC GLP-1, and ARC GLP-1 plus glibenclamide. E: Coinfusion of glibenclamide into the ARC prevented GLP-1–induced inhibition of glucose production. F: Coinfusion of glibenclamide into the ARC prevented GLP-1–induced inhibition of glucose uptake. *P < 0.05 vs. saline. †P < 0.05 vs. saline and i3vt. ‡P < 0.05 vs. saline and GLP-1 plus glibenclamide.