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. 2008 Aug;57(8):2211–2219. doi: 10.2337/db08-0130

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Copyright © 2008, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Activation of human and mouse GPR40 by fatty acids and small-molecule agonists. Representative dose responses of various fatty acids induced calcium mobilization in CHO cells stably expressing human (A) and mouse GRP40 (B) measured by the FLIPR assay. EC₅₀ values for various fatty acids are means ± SE of three independent titration experiments. C: Chemical structures of the small-molecule GPR40 agonists and their dose responses (EC₅₀) measured in the FLIPR-based calcium mobilization assay. D: IP₃ accumulation assay for GPR40 agonists in human GPR40-HEK293 stable cells.