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Hypothalamic POMC mRNA levels measured by qPCR. The 48 h of fasting caused a significant reduction of POMC mRNA levels, which were reversed by intracerebroventricular administration of apoE (8 μg). Data are means ± SE, n = 7. *P < 0.05 vs. the ad libitum–fed saline group. #P < 0.05 vs. 48-h–fasted saline controls.
