Figure 5.
Profile of 4-OCH3E1(E2) metabolites and depurinating DNA adducts in MCF-10F cells treated with Resv and/or 4-OHE2. (A) Levels of 4-OCH3E1(E2) in culture medium of cells treated with 4-OHE2 with or without Resv. (B) Levels of depurinating DNA adducts in culture medium from cells treated with 4-OHE2 with or without Resv. The levels of DNA adducts in Resv-treated cells were significantly lower than those in the cells not treated with Resv, p< 0.05 as determined by ANOVA.