Table 2.
Genes involved in cellular transport differentially expressed in the colon of wild-type and NHE3−/− mice
| Gene | Description | Fold Change | ||
|---|---|---|---|---|
| Ion transporter activity | ||||
| SLC6A19 | Solute carrier family 6 (neutral amino acid transporter), member 19 | 12.4 | ||
| ATP12A | Atpase, H+/K+ transporting, nongastric, alpha polypeptide | 11.4 | ||
| SLC2A4 | Solute carrier family 2 (facilitated glucose transporter), member 4 | 6.6 | ||
| SLC36A1 | Solute carrier family 36 (proton/amino acid symporter), member 1 | 4.53 | ||
| TFRC | Transferrin receptor (p90, CD71) | 4.05 | ||
| SLC11A2 | Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 3.82 | ||
| SLC6A4 | Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 3.62 | ||
| SLC20A1 | Solute carrier family 20 (phosphate transporter), member 1 | 2.69 | ||
| ATP6V1E2 | Atpase, H+ transporting, lysosomal 31 kda, V1 subunit E2 | 2.69 | ||
| SLC6A8 | Solute carrier family 6 (neurotransmitter transporter, creatinine), member 8 | 2.64 | ||
| SLC28A2 | Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 | 2.54 | ||
| LOC381417 | Similar to solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 | 2.52 | ||
| SLC26A6 | Solute carrier family 26, member 6 | 2.4 | ||
| SLC28A3 | Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 | 2.39 | ||
| COX7A1 | Cytochrome c oxidase subunit viia polypeptide 1 (muscle) | 2.28 | ||
| ATP1A1 | Atpase, Na+/K+ transporting, alpha 1 polypeptide | 2.19 | ||
| SLC26A3 | Solute carrier family 26, member 3 | 2.17 | ||
| OCA2 | Oculocutaneous albinism II | 2.15 | ||
| SLC34A2 | Solute carrier family 34 (sodium phosphate), member 2 | 2.05 | ||
| SLC30A1 | Solute carrier family 30 (zinc transporter), member 1 | 2.00 | ||
| SLC13A3 | Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 | 1.79 | ||
| ATP11A | Atpase, class VI, type 11A | 0.47 | ||
| SLC8A1 | Solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.47 | ||
| SLC39A10 | Solute carrier family 39 (zinc transporter), member 10 | 0.46 | ||
| CMAH | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase) pseudogene | 0.43 | ||
| Ion channel activity | ||||
| SCNN1G | Sodium channel, nonvoltage-gated 1, gamma | 245.1 | ||
| FXYD4 | FXYD domain containing ion transport regulator 4 | 39.5 | ||
| CLCA6 | Chloride channel, calcium activated, family member 6 | 32.6 | ||
| SCNN1B | Sodium channel, nonvoltage-gated 1, beta | 5.84 | ||
| BEST2 | Bestrophin 2 | 4.43 | ||
| KCNB2 | Potassium voltage-gated channel, Shab-related subfamily, member 2 | 4.31 | ||
| TMEM37 | Transmembrane protein 37 | 3.77 | ||
| CLIC5 | Chloride intracellular channel 5 | 3.19 | ||
| TRPM6 | Transient receptor potential cation channel, subfamily M, member 6 | 2.99 | ||
| KCNMB4 | Potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 2.63 | ||
| CLCA4 | Chloride channel, calcium activated, family member 4 | 2.09 | ||
| PLLP | Plasma membrane proteolipid (plasmolipin) | 2.08 | ||
| CLIC4 | Chloride intracellular channel 4 | 0.48 | ||
| KCNN4 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 0.44 | ||
| KCTD14 | Potassium channel tetramerisation domain containing 14 | 0.43 | ||
| CLIC1 | Chloride intracellular channel 1 | 0.39 | ||
| Water transport activity | ||||
| AQP8 | Aquaporin 8 | 2.08 | ||
| AQP1 | Aquaporin 1 | 0.47 | ||
Genes were up- or downregulated ≥2-fold; n = 3 groups per genotype, each group comprised of 3 mice; P ≤ 0.05. Genes were selected based on their biological process (transport) and further assigned to functional subcategories according to their molecular function. Genes are sorted according to fold change within the subcategories.