Table 3.
Well-annotated genes involved in immune/inflammatory response differentially expressed in wild-type and NHE3−/− mice
| Gene Name | Description | Fold Change |
|---|---|---|
| DEFB1 | Defensin beta 1 | 37.50 |
| NOS2A* | Nitric oxide synthase 2, inducible, macrophage | 19.60 |
| CHF | Complement factor h | 10.08 |
| ADA | Adenosine deaminase | 9.16 |
| CXCL16 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 5.66 |
| CXCL2 (MIP2)* | Chemokine (C-X-C motif) ligand 2 | 5.05 |
| SAA2 | Serum amyloid A 2 | 5.04 |
| SAA3 | Serum amyloid A 3 | 4.25 |
| IL1RN | Interleukin 1 receptor antagonist | 3.35 |
| POU2F2 | POU class 2 homeobox 2 | 3.31 |
| CD14 | CD14 molecule | 3.19 |
| C3 | Complement component 3 | 3.06 |
| LTIRB3 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 3.05 |
| OLR1 | Oxidized low density lipoprotein (lectin-like) receptor 1 | 2.91 |
| CCL20 | Chemokine (C-C motif) ligand 20 | 2.85 |
| GZMA | Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 2.81 |
| TNFRSF1B | Tumor necrosis factor receptor superfamily, member 1b | 2.75 |
| MAF | Avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog | 2.71 |
| OTUB1 | OTU domain, ubiquitin aldehyde binding 1 | 2.71 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 2.70 |
| FCER1G | Fc receptor, IgE, high affinity I, gamma polypeptide | 2.63 |
| CFB | Complement factor B | 2.62 |
| CCL8 | Chemokine (C-C motif) ligand 8 | 2.57 |
| PGLYRP1 | Peptidoglycan recognition protein 1 | 2.55 |
| IL1B* | Interleukin 1 beta | 2.30 |
| SAA1 | Serum amyloid A 1 | 2.30 |
| C3AR1 | Complement component 3a receptor 1 | 2.26 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 2.26 |
| CCL28 | Chemokine (C-C motif) ligand 28 | 2.23 |
| IL2RA | Interleukin 2 receptor, alpha | 2.21 |
| CLEC2H | C-type lectin domain family 2, member h | 2.20 |
| SYK | Spleen tyrosine kinase | 2.19 |
| ICOSLG | Inducible T-cell co-stimulator ligand | 2.09 |
| CXCL16 | Chemokine (C-X-C motif) ligand 16 | 2.05 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.02 |
| H2-T23 | Histocompatibility 2, T region locus 23 | 2.01 |
| IL18* | Interleukin 18 (interferon-gamma-inducing factor) | 2.01 |
| PAG1 | Phosphoprotein associated with glycosphingolipid microdomains 1 | 1.95 |
| CCL6 | Chemokine (C-C motif) ligand 6 | 0.47 |
| CCL9 | Chemokine (C-C motif) ligand 9 | 0.46 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.44 |
| CD1d1 | CD1d1 antigen | 0.44 |
| THBS1 | Thrombospondin 1 | 0.40 |
| FABP4 | Fatty acid binding protein 4, adipocyte | 0.12 |
| PNLIPRP2 | Pancreatic lipase-related protein 2 | 0.12 |
| ANG4 | Angiogenin, ribonuclease A family, member 4 | 0.04 |
These 46 genes were up- or downregulated ≥2-fold; n = 3; P ≤ 0.05. Asterisks next to the gene symbol indicate genes selected and confirmed by real-time RT-PCR and/or ELISA analysis. Fold change was calculated relative to normalized gene expression in wild-type littermates.