Fig. 2.

Growth curves and HCl secretion in F6 generation Lasp-1-null mice. A: matched male littermates, F6 generation. Body weights of Lasp-1-null mice were slightly lower (0.8–1.6 g) than their WT littermates. Values are means ± SE. N = 14 animals/group. Two-way ANOVA, significantly different by time, P < 0.001 and by genotype, P < 0.01; Bonferroni posttest, *P < 0.05 significantly different from WT. B: basal and histamine-stimulated gastric acid secretion in male littermates. Mice (3 mo of age) were fasted overnight then injected with the H1-receptor antagonist, chlorimpiramine (0.3 mg/kg), followed by saline (basal) or histamine (45 min, 10 mg/kg). Gastric contents were titrated to pH 6.5 with NaOH (B). +/+, WT; +/− heterozygotes; −/− Lasp-1 KO mice. *P < 0.05, N = 8–10.