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. 2008 May 15;295(1):G37–G44. doi: 10.1152/ajpgi.90247.2008

Fig. 4.

Fig. 4.

Aminopyrine (AP) accumulation in gastric glands isolated from WT and Lasp-1−/− mice. A: time courses of basal (ranitidine-inhibited) and histamine-stimulated AP accumulation. Ranitidine (Ranit, 50 μM) was added immediately before incubation. Histamine (Hist, 10 μM) was added to glands after a 10-min temperature equilibration at 37°C. Values shown are means ± SE, N = 5 independent experiments, 8–10 mice/experiment, *P < 0.05. B: time course of decline in histamine-stimulated AP accumulation upon addition of the H2-receptor antagonist, ranitidine. Drug concentrations were the same as in A. Values are means ± SE, N = 4–6 independent experiments, 8–10 mice/experiment, *P < 0.05. Average T1/2 values for ranitidine inhibition in Lasp-1−/− and Lasp-1+/+ glands were 14.1 and 7.9 min, respectively (P < 0.05).