Intraplantar injection of LY blocked the APDC-induced inhibition so that rats in this group had flinching (A) and L/L (B) behaviors that were no different from those receiving PBS, FM. The LY effects on flinching (C) and L/L (D) are shown over a 60 min period. (*indicates significant difference comparing phase 1 from each group to phase 1 PBS, FM group or comparing phase 2 from each group to phase 2 PBS, FM group, p < 0.05, one-way ANOVA followed by a student-Newman-Keuls test ).