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. Author manuscript; available in PMC: 2009 Jun 23.
Published in final edited form as: Neuroscience. 2008 Apr 16;154(2):754–766. doi: 10.1016/j.neuroscience.2008.03.084

Fig. 5.

Fig. 5

A) At 20 min post-injection, intraplantar IS (20 μl) resulted in a significant change from baseline with a decrease in threshold compared to vehicle (PBS), indicating the presence of mechanical allodynia. Addition of 0.5 μM APDC blocked the IS-induced mechanical sensitivity. IS in one paw (ipsil) and APDC in the contralateral (contra) paw resulted in behavior no different from IS alone (* indicates significant difference compared to PBS and APDC/IS group; p < 0.05, one-way ANOVA followed by a student-Newman-Keuls test). B) The APDC-induced inhibition of mechanical sensitivity lasted for at least 60 min post-injection.