Table 2.

Differentially expressed genes in hypertrophy

Gene Name	Gene Expression		Correlation With LVW
	Fold Change	P Value	RC	P Value
Increased expression with hypertrophy
Precursor ANP	5.18	0.0089	329.0	0.0003
Precursor BNP	2.08	0.0012	312.0	0.0023
Prepro-endothelin-1	1.86	0.0228	168.7	0.0018
Decreased expression with hypertrophy
NF-κB p105*	0.85	0.0297	NS
STAT 1*	0.82	0.0264	NS
Caveolin 2	0.81	0.0038	−248.7	0.0069
p38*	0.79	0.0130	NS
NFATc1*	0.78	0.0324	NS
VEGF*	0.78	0.0249	NS
S6 kinase†	0.75	0.0219	−200.4	0.0303
Phospholamban*	0.75	0.0076	−213.3	0.0233
JAK3*	0.74	0.0050	−262.9	0.0123
SAPK/JNK*	0.73	0.0256	NS
ROCK1*	0.72	0.0216	NS
Akt-2*	0.71	0.0010	−229.0	0.0153
p47phox	0.71	0.0011	−390.8	0.0171
β1-Adrenergic receptor*	0.70	0.0009	−508.0	0.0196
SOD2	0.69	0.0148	NS
Calcineurin A	0.67	0.0035	NS
Bcl-2	0.67	0.0075	NS
ERK2	0.67	0.0017	NS
ɛPKC*	0.66	0.0045	−416.2	0.0056
RBCK1*	0.65	0.0046	−418.6	0.0265
Cardiotrophin-1	0.63	0.0027	NS
SERCA2a*	0.62	0.0002	−506.2	0.0059
Dystrophin*	0.61	0.0062	−438.3	0.0384
Ryanodine receptor 2*	0.59	0.0319	NS

Values are indicated with means with P values. List of genes with expression in the myocardium that changed in 11-wk-old hypertensive (HT) rats relative to age-matched normotensive rats is shown at left. Individual regression analysis between change in gene expression and the ratio in left ventricular weight (LVW)/body weight (BW) was carried out. Genes that significantly correlated (P < 0.05) with change in LVW/BW are listed at right. RC, regression coefficient; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; NS, not significant; NFAT, nuclear factor of activated T-cells; ROCK, Rho-associated kinase-β; RBCK, RBCC protein interacting with PKC; SERCA2a, sarco(endo)plasmic reticulum Ca²⁺-ATPase 2a.

^*Genes with expression that went back to normal in 17-wk-old HT rats;

^†genes with expression upregulated over control in 17-wk-old HT rats.