Fig. 5.

MLN353 treatment reduces proteasome activity in mouse heart. A: Kaplan-Meier plot of survival curves of vehicle- and MLN353-treated mice 9 days after CVB3 infection. The numbers in parentheses at 9 days after infection are the numbers of surviving mice over the numbers of total experimental mice. P > 0.05 vs. vehicle-treated mice by log-rank test. B: A/J mice were sham infected with PBS or CVB3 infected and treated with vehicle or MLN353. At 9 days after infection, heart homogenates were prepared and proteasome activity was measured as described in Fig. 1. Results are means ± SE of 3 independent measurements from each animal (vehicle group: n = 9; MLN353 group: n = 11). *P < 0.05 vs. vehicle-treated mice at 9 days after infection.