Fig. 5.
Effects of the lipoxygenase (LO) inhibitor BW755C (BW) and the IKCa channel inhibitor charybdotoxin (CTX) on the vascular activity in rabbit mesenteric arteries. Arterial rings (n = 8–12) were pretreated with Indo (10−5 M) and Nω-nitro-l-arginine (l-NNA; 3 × 10−5 M) with vehicle, or BW755C (10−4 M), or CTX (2 × 10−7 M), or both CTX and BW755C; they were precontracted with phenylephrine (10−7 to 10−6 M), and relaxations to cumulative concentrations of ACh were determined. Data are expressed as percent relaxations, and each value represents mean ± SE. All symbols are as defined in A.