Fig. 7.

Quantitative comparison of distinguished metabolic biomarkers for IL-1β+TNF-α-treated mice, which shows the reversible nature of the metabolic derangement induced by the cytokines. The energy balance was calculated as ATP-to-ADP ratios and the energy charge as [(ATP + 0.5ADP)/(ATP + ADP + AMP)]. All measured indexes were different from control at 6 h (*P ≤ 0.03), with the exception of ADP. Differences were also evident between the 6 h and 24 h time points (+P < 0.05). By 24 h, ATP levels and the lactate-to-glucose ratio had recovered to control levels (P = 0.11 and P = 0.07, respectively). The amount of ADP increased over the study's time course, most likely because of injury-induced increase in energy production. Data are means ± SE of 3 or 4 animals/group.