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. 2008 Apr 25;295(1):L44–L53. doi: 10.1152/ajplung.00448.2007

Fig. 3.

Fig. 3.

SOD activity modulation by ceramides and Cu/Zn SOD transgenic overexpression. A: expression levels of human Cu/Zn SOD in the lung of wild-type (WT) mice (lanes 1–4) and transgenic (Tg) mice (lanes 5–10) detected by Western blot with species-specific Cu/Zn SOD antibody. B: SOD activity levels in the lungs of WT and Cu/Zn SOD transgenic mice measured 48 h after intratracheal vehicle (Veh) or ceramide (Cer) instillation. SOD activity was measured in lung lysates and normalized by protein concentration (means + SD; *P = 0.03 vs. Veh-Wt; **P < 0.05 vs. WT). Number of animals studied: WT + Veh, n = 5; WT + Cer, n = 4; Tg + Veh, n = 5; Tg + Cer, n = 8.