Fig. 5.
Blocking of voltage-dependent Ca2+ channels (VDCC) inhibits force oscillations in Slo−/− CCSM strips and in Slo+/+ with IBTX. A and B: representative recordings from a PE-precontracted Slo+/+ (left) and a Slo−/− (right) CCSM strip in the absence (A) and presence (B) of IBTX that demonstrate the effect of blocking VDCC with nisoldipine. C: average oscillation amplitudes of Slo+/+ and a Slo−/− CCSM strip in the absence and presence of IBTX, before and after adding nisoldipine. D: summary of total relaxation of PE-precontracted CCSM strips induced by nisoldipine as shown in A and B. NIS, nisoldipine; N, no. of mice; *P < 0.05 vs. Slo+/+ untreated.