Table 2.
Time series expression profile for upstream components of PKC, MAPK, PI3K, PKA, and SNARE pathways
| 60 | 75 | 90 | 105 | 120 | Gene Name | |
|---|---|---|---|---|---|---|
| −0.19 | −0.24 | AC | Adenylate cyclase 3 | |||
| −0.20 | −0.17 | AC | Adenylate cyclase 4 | |||
| −0.27 | −0.32 | AC | Adenylyl cyclase 8 | |||
| 0.18 | AC | Adenylate cyclase 5 | ||||
| 0.36 | −0.45 | AC | Adenylate cyclase 9 (predicted) | |||
| 0.41 | −0.40 | −0.26 | −0.38 | PKA | Protein kinase, cAMP dependent regulatory, type I, alpha | |
| 0.28 | −0.27 | −0.27 | PKA | Protein kinase, cAMP-dependent, regulatory, type 2, alpha | ||
| −0.53 | PKA | Protein kinase, cAMP dependent regulatory, type I, beta | ||||
| −0.52 | PKA | Protein kinase, cAMP dependent regulatory, type II beta | ||||
| −0.33 | PKA | Sperm autoantigenic protein 17 | ||||
| −0.28 | −0.30 | PI3K | Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 | |||
| 0.43 | PI3K | Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 | ||||
| 0.16 | PI3K | Phosphoinositide-3-kinase, class 2, beta polypeptide (predicted) | ||||
| 0.29 | PI3K | Phosphoinositide-3-kinase, class 3 | ||||
| 0.93 | PI3K | Phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) | ||||
| 0.27 | −0.15 | PI3K | Phosphatidylinositol 4-kinase, catalytic, beta polypeptide | |||
| 0.44 | PI3K | Ataxia telangiectasia mutated homolog (human) (mapped) | ||||
| 0.27 | PI3K | Similar to Expressed sequence BB220380 | ||||
| −0.24 | 0.24 | 0.25 | Gqa | Guanine nucleotide binding protein, alpha 11 | ||
| 0.41 | Gqa | Guanine nucleotide binding protein, alpha q polypeptide | ||||
| −0.15 | PLC | Phospholipase C, beta 3 | ||||
| −0.20 | PLC | Phospholipase C, beta 4 | ||||
| −0.31 | −0.55 | PLC | Phospholipase C, epsilon 1 | |||
| −0.45 | PLC | Phospholipase C, delta 1 | ||||
| 0.44 | 0.15 | PLC | Phospholipase C, delta 4 | |||
| 0.18 | PLC | Phospholipase C-like 2 (predicted) | ||||
| −0.18 | −0.29 | PKC | Protein kinase C, beta 1 | |||
| 0.26 | −0.29 | PKC | Protein kinase C, delta | |||
| −0.32 | PKC | Protein kinase C, epsilon | ||||
| −0.48 | PKC | Protein kinase C, zeta | ||||
| −0.32 | −0.27 | PKC | Protein kinase C, eta | |||
| 1.03 | 0.66 | RAS | RAB1, member RAS oncogene family | |||
| 0.38 | 0.15 | 0.37 | RAS | RAB8B, member RAS oncogene family | ||
| 0.34 | RAS | RAB10, member RAS oncogene family | ||||
| 0.27 | RAS | RAB13, member RAS oncogene family | ||||
| 0.59 | RAS | RAB28, member RAS oncogene family | ||||
| 0.42 | RAS | Kirsten rat sarcoma viral oncogene homolog 2 (active) | ||||
| 0.42 | RAS | Related RAS viral (r-ras) oncogene homolog 2 | ||||
| 0.24 | 0.34 | −0.14 | −0.23 | RAS | RAB25, member RAS oncogene family (predicted) | |
| 0.22 | RAS | RAB11a, member RAS oncogene family | ||||
| 0.95 | RAS | RAB11B, member RAS oncogene family | ||||
| −0.33 | −0.38 | SNARE | Vesicle-associated membrane protein 1 | |||
| −0.51 | SNARE | Vesicle-associated membrane protein 2 | ||||
| −0.44 | SNARE | Vesicle-associated membrane protein 8 | ||||
| −0.21 | SNARE | Vesicle transport through interaction with t-SNAREs | ||||
| −0.28 | SNAP29 | Synaptosomal-associated protein 29 | ||||
| −0.20 | −0.40 | STX | Epimorphin | |||
| 0.29 | 0.24 | STX | Syntaxin 3 | |||
| 0.26 | 0.30 | STX | Syntaxin 4A (placental) | |||
| 0.60 | STX | Syntaxin 12 |
Bold values denote downregulation; italic values denote upregulation. The upstream components of PKC, MAPK, phosphatidylinositol 3-kinase (PI3K), PKA, and soluble N-ethylmalemide sensitive fusion protein attachment receptor (SNARE) pathways are coordinately regulated in response to a 1-h acute hypertensive pulse. 60, 75, 90, 105, and 120 in the header row correspond to minutes after hypertensive stimulus began (see Fig. 1). RAS, renin angiotensin system. The numbers are log-fold change in expression.