Table 4.
Tabular representation of connections between receptors and pathways for receptors implicated in baroreflex function by pharmacological studies
| Receptor Name | Bradycardic | PKC | MAPK | PI3K | PKA |
|---|---|---|---|---|---|
| CB1 | 1–3 | X 4 | X 5 | X 5 | 5 |
| 5HT2 | 6, 7 | 8, 9 | |||
| AMPA | 10–12 | 13–15 | 16 | 16 | |
| Estrogen | 17, 18 | 19 | 19, 20 | 19, 20 | 19 |
| NMDA | 12, 24, 25 | 26 | 26 | ||
| NK1 | 10, 27, 28 | 29 | X 30 | ||
| mGluR group 1 | 31 | 32 | 33 | X 32 | |
| P2X Purinoreceptor | 34, 35 | ||||
| α2-adrenergic | 36–38 | 39, 40 | 40 | 41 | |
| P1 purinoreceptor | 34 | ||||
| Atrial natriuretic peptide | 46 | ||||
| Delta opioid | 48 | 49 | 49 | 49 | X 50 |
| Insulin | 51 | 52 | 53 | 51, 53 | 53 |
| NPY Y1 | 55–58 | 59 | 59 | ||
| Endothelin-A | 62, 63 | 64 | 64 | 64 |
| Tachycardic | PKC | MAPK | PI3K | PKA | |
|---|---|---|---|---|---|
| 5HT3 | 6, 66–70 | ||||
| Nociceptin (ORL1) | 71, 72 | 73 | X 5 | X 5 | X 73 |
| GABAA | 62, 74, 75 | 76 | |||
| GABAB | 62, 78 | 79 | 80 | ||
| mu opioid | 85 | X 5 | X 5 | X 5 | X 5 |
| ANG II | 86 | 87 | 88 | 89, 90 | X 91 |
| Adrenomedullin | 92 | 93 | 94 | 95 | 92 |
| Vasopressin 1 | 96 | 97 | 97 | ||
| NPY Y2 | 100 |
Tachycardic and bradycardic refer to the physiological response associated with binding of the receptor in the nucleus tractus solitarius (NTS). Numbers cite which studies found each connection and correspond to the supplemental references. X denotes no interaction found. Figure 3 is a graphical representation of the connections shown in this table. NPY, neuropeptide Y.