Table 5.

Enrichment analysis using Fisher's exact test was performed on each pathway at each time point

Pathway	Time	Up/Down	P Value
Ionotropic glutamate receptor pathway	60	up	0.004
Metabotropic glutamate receptor group III pathway	60	up	0.006
5HT2 type receptor-mediated signaling pathway	60	down	0.020
Angiotensin pathway	90	up	0.024
Insulin IGF pathway-protein kinase B signaling cascade	90	up	0.033

Pathways from in silico model significantly enriched for up- or down-regulated genes at all time points. P value indicates statistically significant results (P < 0.05). Time after beginning of hypertensive stimulus is given in column 2, and direction of gene expression regulation is given in column 3. A complete list of P values is provided in Supplemental Tables S3–S5.