Table 3.

In vivo hemodynamics in 28-mo-old mice exposed to filtered air (FA) or carbon black (CB)

	FA	CB
LV Pressures and Volumes
Systolic pressure, mmHg	105±3	102±8
Diastolic pressure, mmHg	77±5	70±9
Mean systemic arterial pressure, mmHg	84±6	75±7
End-systolic volume, ml	16.8±1.7	20.1±1.4*
End-diastolic volume, ml	31.0±1.8	38.2±1.9*
PWRmax/EDV, mmHg/s	28.6±0.5	22.0±1.1*
dP/dtmax, ms	13429±488	10231±508*
Ejection fraction, %	64.5±2.7	56.0±3.1*
Tau, ms	6.5±0.4	7.0±0.8
Heart rate, beats/min	602±22	631±26
Cardiac output, ml/min	13.9±1.3	14.6±2.7
Total peripheral resistance, mmHg·ml−1·min−1	5.96±0.6	5.18±0.7
Heart weight, mg	147±4	149±5
RV Pressure-Volume Loop Results
RV systolic pressure, mmHg	14.3±0.5	22.4±0.6*
RV diastolic pressure, mmHg	3.1±0.3	5.4±0.3*
Mean right atrial pressure, mmHg	4.0±0.4	4.9±0.2*
dP/dtmax, ms	2943±124	2486±97*
dP/dt/IP	254±14	208±20*
Tau, ms	7.1±0.2	9.6±0.4*
Pulmonary Pressures
Systolic pulmonary arterial pressure, mmHg	13.3±0.5	23.6±0.6*
Diastolic pulmonary arterial pressure, mmHg	8.0±0.4	14.6±0.5*
Mean pulmonary arterial pressure, mmHg	10.1±0.4	17.4±0.6*
Mean pulmonary arterial wedge pressure, mmHg	4.0±0.4	5.7±0.3*
Pulmonary vascular resistance, mmHg·ml−1·min−1	0.43±0.05	0.80±0.04*

Data are means ± SE; n = 4 mice/exposure group. RV, right ventricular; IP, instantaneous pressure.

^*P < 0.05, CB vs. FA.