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Referred hyperalgesia associated with acute (A) and subacute (B) acrolein-induced cystitis was reversed by systemic treatment with nerve growth factor (NGF)-neutralizing antiserum [NGF antibody (Ab)]. Treatment with normal rabbit serum did not affect referred hyperalgesia. Values are means ± SE (n = 4–6). **P < 0.01 vs. baseline. #P < 0.05 vs. normal serum.
