Table 1.
Resting MAP and HR, plasma and hippocampus aldosterone and corticosterone, and plasma ANG II in Wistar rats treated with ICV infusion of aCSF or Na+-rich aCSF with or without concomitant ICV infusion of FAD286 for 2 wk
|
aCSF |
Na+-Rich aCSF
|
|||
|---|---|---|---|---|
| Without FAD | With FAD | Without FAD | With FAD | |
| MAP, mmHg | 105±2 | 104±1 | 121±2* | 113±2† |
| HR, beats/min | 401±11 | 411±14 | 433±29 | 419±12 |
| Plasma | ||||
| Aldosterone, pg/ml | 984±135 | 892±132 | 977±112 | 974±158 |
| Corticosterone, ng/ml | 557±36 | 449±60 | 541±34 | 512±71 |
| ANG II, pg/ml | 24±4 | 26±5 | 36±8 | 35±11 |
| Hippocampus | ||||
| Aldosterone, pg/g | 491±112 | 587±117 | 657±152 | 524±178 |
| Corticosterone, ng/g | 62±11 | 76±13 | 87±15 | 74±11 |
Data are means ± SE (n = 6–8). MAP, mean arterial pressure; HR, heart rate; ICV, intracerebroventricular; aCSF, artificial cerebrospinal fluid; FAD, FAD286.
*
P < 0.05 vs. others.
†
P < 0.05 vs. aCSF with or without FAD.