Fig. 5.
Effect of Ova sensitization on the average responses of pulmonary C fibers to lung inflation in anesthetized, open-chest, and artificially ventilated rats. Top and bottom: average responses to lung inflation at Ptr of 15 and 30 cmH2O, respectively. Open bars, control rats (n = 13); filled bars, sensitized rats (n = 16 in left, and n = 15 in right). Responses were tested both before and 5–25 min after acute Ova challenge (3%, 5 min) in both control and sensitized rats. Values are means ± SE. ΔFA, difference between the average FA over the 10-s interval during lung inflation and the average baseline FA (over 60 s) in each fiber. *P < 0.05, significant difference in responses between control and sensitized rats. †P < 0.05 and ††P < 0.01, significant difference in responses between before and after acute Ova challenge in either control or sensitized rats.