Overall vasodilation in response to the SLH in part 2. Antagonism of α- and β-receptors, Y1 receptors, or α-, β-, and Y1 receptors significantly decreases the overall level of vasodilation (expressed as CVC %max) achieved in response to SLH to 40°C in part 2. The decreases in the response among the treated sites were not significantly different. The + and − indicate sites were or were not treated with antagonists, respectively. Values are means ± SE; n = 7 subjects. *P < 0.05 vs. untreated control.