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. 2008 May 8;105(1):249–259. doi: 10.1152/japplphysiol.00052.2007

Fig. 8.

Fig. 8.

Leptin treatment in ob/ob mice significantly upregulated the gene expression of procollagen I (Col1a1), III (Col3a1), and VI (Col6a3), insulin-like growth factor binding protein-2 (Igfbp2), matrix metalloproteinase 2 (Mmp2), signal transducer and activator of transcription 1 (Stat1) in lung tissue, and transforming growth factor-β-inducible early growth response 1 (Tieg1). The gene expression levels of elastin (Eln), leptin receptor (Lepr), insulin-like growth factor I (Igf1), insulin-like growth factor binding protein-2 (Igfbp2) and -4 (Igfbp4), serine peptidase inhibitor h1 (Serpinh1), and the surfactant proteins a1 (Sftpa1), b (Sftpb), c (Sftpc), and d (Sftpd) were not significantly altered by leptin treatment in ob/ob mice. Average values (±SE) are derived from quantitative PCR data referenced to the expression levels of GADPH. The vertical line at a gene expression level of 1 represents no detectable change in expression. †P < 0.05, leptin vs. saline treatment.