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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Exp Neurol. 2008 Mar 7;211(2):449–455. doi: 10.1016/j.expneurol.2008.02.022

TABLE 2.

Effects of Intrathecal Administration of PACAP on Micturition Reflexes of Spinal Cord Transected Rats with Intact or Bilaterally Sectioned Hypogastric Nerves, during Continuous Infusion Cystometrograms

BCA MVP PT BRP BCD ICI
(cm H2O) (cm H2O) (cm H2O) (cm H2O) (s) (s)
Transected SC + Intact HGN
   PACAP (10 µg) (n=4–5)
     before 33.9 ± 1.9 42.0 ± 2.5 9.0 ± 1.8 8.6 ± 1.3 50 ± 9 18 ± 5
     after 12.2 ± 7.9* 27.3 ± 5.8* 12.5 ± 1.3* 17.0 ± 3.3 43 ± 8* 10 ± 4
   PACAP (30 µg) (n=4–5)
     before 33.5 ± 1.8 40.6 ± 1.7 8.6 ± 1.7 7.2 ± 1.5 64 ± 4 32 ± 3
     after 3.1 ± 3.1** 18.2 ± 5.1* 12.6 ± 2.6* 17.7 ± 4.1* 53 ± 4** 21 ± 7
Transected SC + Sectioned HGN
   PACAP (10 µg) (n=5)
     before 27.8 ± 5.1 38.5 ± 7.1 10.7 ± 2.5 10.3 ± 2.3 52 ± 5 14 ± 6
     after 12.2 ± 2.2** 27.4 ± 4.4 16.4 ± 3.3* 16.8 ± 2.1* 43 ± 4* 19 ± 5
   PACAP (30 µg) (n=5)
     before 23.9 ± 4.6 34.6 ± 6.3 11.4 ± 2.9 9.9 ± 2.5 54 ± 7 39 ± 25
     after 2.5 ± 1.7** 18.3 ± 4.4* 17.9 ± 3.1** 16.2 ± 2.2* 41 ± 7** 29 ± 14

Note. BCA, bladder contraction amplitude; MVP, maximal voiding pressure; PT, pressure threshold; BRP, baseline resting pressure; BCD, bladder contraction duration; ICI, intercontraction interval; SC, spinal cord; HGN, hypogastric nerves.

*

P<0.05

**

P<0.01 (paired t test), compared “after” to “before” the i.t. injection of PACAP.