TABLE 3.

Effects of Intrathecal Administration of PACAP on Micturition Reflex of Spinal Cord Intact Rats with Intact or Bilaterally Sectioned Hypogastric Nerves, during Continuous Infusion Cystrometrograms.

	BCA	MVP	PT	BRP	BCD	ICI
	(cm H2O)	(cm H2O)	(cm H2O)	(cm H2O)	(s)	(s)
Intact SC + Intact HGN
PACAP (10 µg) (n=5)
before	28.8 ± 5.7	32.6 ± 6.8	6.8 ± 1.6	5.8 ± 1.8	36 ± 5	96 ± 32
after	29.6 ± 4.3	34.6 ± 6.6	8.2 ± 2.6	7.0 ± 2.4	39 ± 3	85 ± 37
PACAP (30 µg) (n=4)
before	26.8 ± 3.5	31.9 ± 5.0	7.2 ± 2.0	6.6 ± 2.2	36 ± 5	107 ± 38
after	33.8 ± 3.7*	41.0 ± 6.8*	9.9 ± 2.7	15.2 ± 6.6	45 ± 5**	88 ± 39
Intact SC + Sectioned HGN
PACAP (10 µg) (n=5)
before	25.3 ± 2.9	32.9 ± 3.2	9.8 ± 2.2	5.9 ± 1.9	53 ± 10	103 ± 33
after	30.5 ± 1.9*	39.2 ± 3.3*	11.3 ± 2.0*	7.9 ± 2.9	63 ± 10	126 ± 23
PACAP (30 µg) (n=5)
before	23.2 ± 3.3	30.7 ± 3.2	9.9 ± 2.0	6.1 ± 1.8	41 ± 11	106 ± 35
after	31.3 ± 1.8*	40.0 ± 3.0**	13.5 ± 2.8*	17.5 ± 2.7**	58 ± 15*	75 ± 41

Note. BCA, bladder contraction amplitude; MVP, maximal voiding pressure; PT, pressure threshold; BRP, baseline resting pressure; BCD, bladder contraction duration; ICI, intercontraction interval; SC, spinal cord; HGN, hypogastric nerves.

^*P<0.05

^**P<0.01 (paired t-test), compared “after” to “before” the i.t. injection of PACAP.