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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 May 1;18(12):3646–3651. doi: 10.1016/j.bmcl.2008.04.065

Table 1.

Synthesis and cathepsin L inhibitory activity of thiocarbazates.

graphic file with name nihms55748f5.jpg
thiocarbazate R1 R2 IC50 (? M)
(-)-1 Boc-l-Trp graphic file with name nihms55748t1.jpg 0.056 ± 0.001
(-)-2 Boc-l-Phe 0.115 ± 0.006
3 Boc-Gly inactive
4 graphic file with name nihms55748t2.jpg 21.797 ± 1.836
(-)-5 Boc-l-Trp graphic file with name nihms55748t3.jpg 0.041 ± 0.002
6 Boc-l-Trp graphic file with name nihms55748t4.jpg 0.110 ± 0.003
(-)-7 Boc-l-Trp graphic file with name nihms55748t5.jpg 0.201 ± 0.012