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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Immunol. 2008 Aug 1;181(3):1728–1736. doi: 10.4049/jimmunol.181.3.1728

Figure 8.

Figure 8

Z-VAD-FMK suppresses 15d-PGJ2-, but not MEHP-, induced Bid cleavage (A) and cytochrome c release (B). Following a 30 min pretreatment with Vh or Z-VAD-FMK (30 μM) and treatment with Vh, 15d-PGJ2 (10 μM), or MEHP for 6 hr, cytoplasmic extracts from digitonin-permeabilized cells were prepared and analyzed by immunoblotting for full-length Bid and cytochrome c. Protein expression levels were quantified as described in the Methods. Data are presented as means ± SE from at least 3 independent experiments. *Statistically different than Vh-treated (p<0.05, ANOVA, Tukey-Kramer). **Statistically different than 15d-PGJ2 alone (p<0.05, ANOVA, Tukey-Kramer).