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. Author manuscript; available in PMC: 2009 Apr 24.
Published in final edited form as: J Med Chem. 2008 Apr 2;51(8):2421–2431. doi: 10.1021/jm701162g

Figure 2.

Figure 2

Agonist-induced β-arrestin2-GFP translocation. HEK-293 cells transfected with MOR1 and βarr2-GFP and with or without GRK2 over-expression were treated with the indicated drugs. Representative cells of at least 3 independent experiments are shown in which several cells were imaged. A. DAMGO induces robust translocation of βarr2-GFP (puncta; arrows) to the plasma membrane. Morphine, however, can only induce translocation when GRK2 is over-expressed. Ester 1c is unable to induce robust βarr2-GFP translocation to the plasma membrane even in the presence of GRK2 over-expression. B. Amide 7b is the only herkinorin derivative that induces βarr2-GFP translocation in the absence or presence of GRK2 over-expression.