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. Author manuscript; available in PMC: 2009 Apr 24.
Published in final edited form as: J Med Chem. 2008 Apr 2;51(8):2421–2431. doi: 10.1021/jm701162g

Figure 3.

Figure 3

Agonist-induced MOR1-YFP internalization. HEK-293 cells stably transfected with MOR1-YFP were treated with the indicated drugs with or without GRK2 over-expression. Representative cells of at least 3 independent experiments are shown in which several cells were imaged. A. DAMGO induces robust internalization of MOR1-YFP (vesicles; arrows). Morphine, however, can only induce robust MOR1-YFP internalization when GRK2 is over-expressed. Ester 1c is unable to induce robust MOR1-YFP internalization even in the presence of GRK2 over-expression. B. Amide 7b is the only herkinorin derivative that can induce MOR1-YFP internalization, even in the in the presence of GRK2 over-expression.