TABLE 5.

Comparison of conformational preferences of gramicidin analogues having Trp → 1-Me-Trp and Trp → Phe substitutions

The areas of peaks for SS and DS conformers in size exclusion chromatograms are compared and reported as the percentage of subunits in the single-stranded conformation.

Substitution position	Trp → 1-Me-Trpa	Trp → Pheb
	% SS	% SS
None	92-99	98
9	79	92
11	98	96
13	90	88
15	99	98
9, 11	61	56
13, 15	78	88
9, 11, 13, 15	30	<18

^aData from Figs. 2 and 3, in DOPC, 23 °C; estimated uncertainty, ±5%.

^bData from Salom et al. (19), in DOPC, 23 °C.