FIGURE 1.

BITC, PEITC, and SFN inhibit A549 cell growth. A, structures of ITCs and NMPEA, an analog of PEITC. B, dose-response growth inhibition after 24-h treatments with BITC (⋄), PEITC (□), SFN (▵), and NMPEA (×); point represents the mean ± S.D. of triplicates. C, phase contrast images of cells after 24-h treatments. Apoptotic cells with shrunken coverage and extensive membrane blebbing appeared after treatment with 10 μm BITC, 10 μm PEITC, and 30 μm SFN. No significant morphological changes were observed in cells treated with vehicle DMSO or 10 μm SFN.