FIGURE 6.

A, cells were transfected or cotransfected either with WT or Δ264 CFTR or with CD4. Note that cotransfection of Δ264 CFTR or WT CFTR with CD4 reduces detectable Δ264 CFTR (compare 1st lane (Δ264 CFTR alone) with 2nd lane (Δ264 CFTR + CD4)) and WT CFTR protein (compare 5th lane (WT CFTR alone) with 4th lane WT CFTR + CD4). This is in sharp contrast to the result with Δ264 CFTR; when cotransfected with WT CFTR, Δ264 CFTR increases detectable CFTR protein (compare 5th with 3rd lane). GAPDH experiments showed equal loading (data not shown), n = 5. B, summary data is shown; only C band density was measured. Data are significantly different.