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Polymerase-based Kd values
|
RT enzyme
|
15-bp hybrid duplex
|
|
|---|---|---|
| Kd(pol) | FCa | |
| nm | -fold | |
| WT | 12.8 ± 2.38 | |
| TAMs | 22.7 ± 3.31 | 1.77 |
| TAMs/A360V | 10.5 ± 1.87 | 0.820 |
| TAMs/N348I | 21.7 ± 1.05 | 1.69 |
| TAMs/A360V/N348I | 11.2 ± 3.29 | 0.875 |
FC, -fold change in Kd(pol) value of each mutant RT was compared with that of WT RT.
