FIGURE 3.

Activation of PKA(II) sensitizes CEM cells to GC treatment. Cell viability of C7–14 and C1–15 cells after treatment with Dex and Dex in combination with cAMP agonists selective for PKA(I), PKA(II), and Epac was measured. FSK, forskolin. p values were indicated by asterisks (relative to vehicle) and pound signs (relative to Dex treatment); single symbol, p < 0.05; two symbols, p < 0.01. Compound concentrations used are as following: Dex, 0.1 μm for C7–14 and 1.00 μm for C1–15; forskolin, 10 μm; PKA agonists, 50 μm; 2me, 100 μm.