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. 2008 Jul 26;64(Pt 8):686–691. doi: 10.1107/S1744309108019623

Figure 2.

Figure 2

(a) Synthesis and chemical structure of Compound 902: 1-(5-methyl-2-trifluoro­methyl-furan-3-yl)-3-(5-{2-[6-(1H-[1,2,4]triazol-3-ylamino)-pyrimidin-4-ylamino]-ethyl}-thiazol-2-yl)-urea. a, 1H-[1,2,4]triazole-3-ylamine, Cs2CO3, DMA; b, [5-(2-aminoethyl)thiazol-2-yl]carbamic acid t-butyl ester, DIEA, t-BuOH; c, HCl, dioxane, DCM; d, 3-isocyanato-5-methyl-2-trifluoromethylfuran, DIEA, DMF. (b) Chemical structure of Compound 065: 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethylphenyl)-urea.