. Author manuscript; available in PMC: 2008 Aug 5.

Published in final edited form as: Genes Immun. 2006 Nov 23;8(1):84–90. doi: 10.1038/sj.gene.6364357

Table 2.

Replication of linkage at chromosomes 6 and 7.

Marker	Chr. Location	Physical Map Location (Mb)	Genethon Location (cM)	São Luis Primary Scan			Natal			São Luis + Natal
Marker	Chr. Location	Physical Map Location (Mb)	Genethon Location (cM)	LOD	Z_lr	P	LOD	Z_lr	P	LOD	Z_lr	P
D6S1581	6q25.3	160.2	165	0.52	1.54	NS	0.03	0.38	NS	0.38	1.33	NS
D6S264	6q27	166.6	179.1	0.57	1.62	0.053	0.99	2.14	0.016	0.71	1.81	0.035
D6S281	6q27	169.7	-^*	0.97	2.11	0.017	0.65	1.73	0.042	1.08	2.22	0.013
D6S446	6q27	170.4	188.4	0.05	0.49	NS	0.32	1.22	NS	0.14	0.79

D7S519	7p13	46.0	70.5	0.75	1.86	0.032	0.13	0.78	NS	0.86	2.00	0.023
D7S502	7q11.22	66.7	79.6	0.60	1.66	0.048	1.04	2.18	0.014	1.34	2.49	0.007

location in Genethon map inconsistent with physical or decode maps; position used based on physical map

Replication for linkage was undertaken for chromosomes 3, 4, 6, 8, 16, and 19 in the Natal families (see Table 1) by genotyping 25 markers from the Applied Biosystems ABI Prism Linkage Mapping Set version 2 (_{Electronic Database Information 2}). Only chromosomes 6 and 7 were independently positive for linkage in Natal. Linkage analysis was performed as before (see legend to Figure 1).